(085) Topical Capsaicin for Provoked Vestibulodynia

Abstract Introduction Provoked vestibulodynia (PVD), occurs when pain is localized in the vulvar vestibule and triggered by any vestibular contact (sexual or otherwise). PVD most common form of vulvodynia there currently no approved treatment. Capsaicin cream hypothesized to improve allodynia patients with neuroproliferative binding vanilloid receptor (TRPV1) on C- afferent nociceptors thereby causing defunctionalization TRPV1. Although capsaicin has been utilized as a treatment for vulvodynia, very little known about its effectiveness improving sexual function. Objective Investigate therapeutic potential PVD. Methods Patients who were prescribed 0.025% compounded VersaBase identified electronic medical record through search physician-entered diagnoses confirmed prescription list from compounding pharmacy. Adult documented included. Female Sexual Dysfunction (FSD) was measured before after Function Index (FSFI) Distress Scale-Revised (FSDS-R). Results Twenty-five responded follow-up questionnaire. Average age at presentation 30 years (range 18-52 years). Self-reported ethnicity study population 76% White, 4% Latina, Asian, Mixed, Middle Eastern, response 8% participants. After consistent daily usage, 80% able tolerate application full 20 minutes. Washing off cold water helpful tolerating 72% patients, found applying topical anesthetic such lidocaine helpful. The median amount time required increase tolerance minutes 1-2 weeks. On VAS scale, mean score while initially 8.96, 10. While 48% improved their pain, 56% would recommend pain. FSDS 35.96 baseline compared 25.09 (p < 0.0001). self-reported 8.2 5.35 using consistently FSFI domain 0.98 2.45 = 0.005). not statistically significant, total 15.44 17.84 follow-up. Conclusions promising Among are significantly decreases should be counseled that severely painful, even use anesthetics lidocaine. Emotional distress trauma reported among application. However, feeling “grateful” “satisfied” considered have failed more conservative treatments proper counseling regarding reviewed. Disclosure No